On 8 August 2025, the European
Commission adopted a regulation amending Annex XVII to REACH (Regulation (EC)
No 1907/2006) concerning carcinogens, germ cell mutagens and reproductive
toxicants (CMRs). This update reflects recent changes to the EU’s harmonised
classification and labelling of chemicals.
New Substances Added to Annex
XVII
The amendment incorporates
substances newly classified as CMR category 1B under Commission Delegated
Regulation (EU) 2024/1973. These substances are now listed in Appendices 2, 4,
and 6 of Annex XVII, meaning that they cannot be supplied to the general public
above the set concentration limits.
Among the substances included
are:
- Diuron (CAS 330-54-1)
- Tetrabromobisphenol-A (CAS 79-94-7)
- N,N-dimethyl-p-toluidine (CAS 99-97-8)
- 4-nitrosomorpholine (CAS 59-89-2)
- 4-methylimidazole (CAS 822-36-6)
- Several phosphonium salts and
diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
- Dibutyltin compounds, including dibutyltin maleate
and dibutyltin oxide
Derogation for Cumene in
Aviation Fuels
The Commission also clarified the
status of cumene (CAS 98-82-8). Although cumene had already been included in
Annex XVII in 2023, the restriction had created practical issues for aviation
fuels used by non-professional pilots. The new regulation introduces a
derogation permitting the use of cumene in kerosene and gasoline for aviation
that meet recognised international standards (e.g. Jet-A, Jet-A1, JP-x, DEF
STAN, ASTM, EN 228).
Entry into Force and
Application
The Regulation will enter into
force 20 days after publication in the Official Journal of the EU. The
restrictions related to the newly classified CMRs will apply from 1 September
2025, in line with the implementation of the updated CLP classifications. The
full text of the Regulation and the Annex can be downloaded here.
